References
[1] Zhan Y, et al. The burden of bipolar disorder in adolescents and young adults: a global, regional, and national perspective from 1990 to 2021 with projections to 2040. J Affect Disord. 2026. doi: 10.1016/j.jad.2025.120463
[2] Zhong QQ, Zuo H, Li JX, Zhu F. Trends in incidences, prevalence cases, and the disability-adjusted life-years of bipolar disorder in China, 1990-2019. J Public Health. 2024.
doi: 10.1007/s10389-024-02147-3
[3] Huang Y, et al. Prevalence of mental disorders in China: a cross-sectional epidemiological study. Lancet Psychiatry. 2019;6(3): 211-224. doi: 10.1016/S2215-0366(18)30511-X
[4] Chen S, et al. Mental health literacy and the stigmatisation and discrimination of individuals affected by mental illnesses in China: a scoping review. Lancet West Pac. 2025.
doi: 10.1016/j.lanwpc.2025.00179
[5] Zhang Y, et al. Prevalence and associated factors of suicidal behaviors among community-dwelling individuals with serious mental disorders—Shandong Province, China, 2022. China CDC Wkly. 2023;5(23):515-520. doi: 10.46234/ccdcw2023.107
[6] Chan JKN, et al. Lithium for bipolar disorder and risk of thyroid dysfunction and chronic kidney disease. JAMA Netw Open. 2025;8(2):e2458608.
doi: 10.1001/jamanetworkopen.2024.58608
[7] McKnight RF, et al. Lithium side effects and toxicity: prevalence and management strategies. Int J Bipolar Disord. 2016;4(1):27.
doi: 10.1186/s40345-016-0047-3
[8] Kronenberg LM, et al. A systematic review of selective serotonin reuptake inhibitor (SSRI)-induced activation and manic/hypomanic switch in children and adolescents. J Child Adolesc Psychopharmacol. 2023. doi: 10.1089/cap.2022.0067
[9] Holmberg JK, et al. Antidepressant use and risk of manic episodes in children and adolescents with depression. JAMA Psychiatry. 2023;80(12):1262-1270.
doi: 10.1001/jamapsychiatry.2023.2809
[10] Ranjbar A, et al. The effect of adding curcumin to sodium valproate in treatment of patients with bipolar disorder in the acute phase of mania: a randomized double-blind clinical trial. Clin Psychopharmacol Neurosci. 2023;21(1):136-145.
doi: 10.9758/cpn.2023.21.1.136
[11] Lopresti AL, et al. Curcumin for the treatment of major depression: a randomised, double-blind, placebo controlled study. J Affect Disord. 2014;167:368-375.
doi: 10.1016/j.jad.2014.06.001
[12] Yaikwawong M, et al. Curcumin reduces depression in obese patients with type 2 diabetes: a randomized controlled trial. Nutrients. 2024;16(15):2414. doi: 10.3390/nu16152414
[13] Yuan J, et al. Potential therapeutic benefits of curcumin in depression or anxiety induced by chronic diseases: a systematic review of mechanistic and clinical evidence. Front Pharmacol. 2025;16:1522671. doi: 10.3389/fphar.2025.1522671
[14] Gazal M, et al. Neuroprotective and antioxidant effects of curcumin in a ketamine-induced model of mania in rats. Eur J Pharmacol. 2014;724:132-139. doi: 10.1016/j.ejphar.2013.12.028
[15] Fu Q, Qiu R, Yao T, Liu L, Li Y, Li X, et al. Curcumin as a preventive intervention for postpartum depression: modulation of synaptic plasticity, oxidative stress, and inflammation in a mouse model. Transl Psychiatry. 2025;15(1):143.
[16] Zhu J, Zhang Y, Ren R, Sanford LD, Tang X. Blood transcriptome analysis: ferroptosis and potential inflammatory pathways in post-traumatic stress disorder. Front Psychiatry. 2022;13:841999.
[17] Cao H, Zuo C, Huang Y, Zhu L, Zhao J, Yang Y, et al. Hippocampal proteomic analysis reveals activation of necroptosis and ferroptosis in a mouse model of chronic unpredictable mild stress-induced depression. Behav Brain Res. 2021;407:113261.
[18] Zhou Y, Huang Y, Ye W, Chen Z, Yuan Z. Cynaroside improved depressive-like behavior in CUMS mice by suppressing microglial inflammation and ferroptosis. Biomed Pharmacother. 2024;173:116425.
[19] Wang Y, Wang S, Xin Y, Zhang J, Wang S, Yang Z, et al. Hydrogen sulfide alleviates the anxiety-like and depressive-like behaviors of type 1 diabetic mice via inhibiting inflammation and ferroptosis. Life Sci. 2021;278:119551.
[20] Fang J, Yuan Q, Du Z, Zhang Q, Yang L, Wang M, et al. Overexpression of GPX4 attenuates cognitive dysfunction through inhibiting hippocampus ferroptosis and neuroinflammation after traumatic brain injury. Free Radic Biol Med. 2023;204:68-81.