Abstract
Resveratrol is a naturally derived polyphenolic compound with antioxidant, anti-inflammatory, and metabolic regulatory properties. Nevertheless, low stability, low water solubility, and low bioavailability greatly limit its applications. Hugeul and Nelson presented a zein/hyaluronic acid (HA) composite nanoparticle delivery system, which was used in this study to encapsulate and protect resveratrol and enhance its physicochemical characteristics and stability. The protein-to-polysaccharide ratio, particle size, polydispersity index (PDI), zeta potential, encapsulation efficiency, loading capacity, and thermal stability were examined systematically by adjusting the ratio. The findings showed that the system with appropriate proportions had high encapsulation efficiency and loading capacity, as well as greatly improved the thermal stability and retention rate of resveratrol. This composite nanoparticle architecture provides improved stability for resveratrol and offers a theoretical basis and technical support for its development in functional foods and pharmaceutical formulations.
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How to cite this paper
Construction of Zein/Hyaluronic Acid Composite Nanoparticles and Their Effects on the Structural Stability of Resveratrol
How to cite this paper: Dora Huang. (2026) Construction of Zein/Hyaluronic Acid Composite Nanoparticles and Their Effects on the Structural Stability of Resveratrol. Advance in Biological Research, 7(1), 11-19.
DOI: http://dx.doi.org/10.26855/abr.2026.06.002