ArticleOpen Access http://dx.doi.org/10.26855/ijcemr.2026.05.012
Correlation Analysis of Clinical Phenotypes, Inflammatory Molecular Markers, and Susceptibility Gene Polymorphisms in Acne Patients in Urumqi and Construction of Treatment Regimens
Reyila Mohetaer1,2, Tashkenbaeva Umida1,*
1Tashkent State Medical University, Tashkent 100109, Uzbekistan.
2Miermei Medical Aesthetic Clinic, Urumqi 830000, Xinjiang, China.
*Corresponding author: Tashkenbaeva Umida
Published: May 25,2026
Abstract
Objective: To investigate the correlation between clinical phenotypes, inflammatory molecular markers, and susceptibility gene polymorphisms in acne patients in Urumqi, and to construct targeted treatment regimens. Methods: A total of 80 acne patients admitted to our hospital from February 2025 to March 2026 were enrolled as the study group, and 40 healthy subjects who received physical examination in our hospital during the same period with normal results were enrolled as the control group. Fasting peripheral blood was collected from both groups for the detection of inflammatory molecular markers. Meanwhile, clinical phenotype evaluation and gene polymorphism analysis were performed on patients in the study group. The clinical phenotypes of acne patients in Urumqi were analyzed, and the levels of inflammatory molecular markers such as tumor necrosis factor-α (TNF-α), interleukin (IL)-6, IL-1β, and IL-8 were compared between the two groups. The polymorphisms of the TNF-α gene and IL gene family, including TNF-α gene -308G>A polymorphism, IL-8 -251T>A polymorphism, and IL-4R Q551R A/G polymorphism, were analyzed between acne patients in Urumqi and healthy populations. The correlation between clinical phenotypes, inflammatory molecular markers, and gene polymorphisms in acne patients in Urumqi was also analyzed. Results: Among the 80 acne patients, as assessed by the modified Pillsbury classification, 21 cases (26.25%) were mild (grade I), 30 cases (37.50%) were moderate (grade II), 16 cases (20.00%) were moderate (grade III), and 13 cases (16.25%) were severe (grade IV). The serum levels of inflammatory molecular markers such as TNF-α, IL-6, IL-1β, and IL-8 in the study group were significantly higher than those in the control group, with statistically significant differences (P < 0.05). For the TNF-α gene -308G>A polymorphism, the distribution of GG, GA, and AA genotype frequencies in acne patients was significantly different from that in the control group (P < 0.05), and carrying the A allele increased the risk of acne. For the IL-8 -251T>A polymorphism, the distribution of TT, TA, and AA genotype frequencies in acne patients was significantly different from that in the control group (P < 0.05), and carrying the T allele increased the risk of acne. For the IL-4R Q551R A/G polymorphism, the distribution of AA, AG, and GG genotype frequencies in acne patients was significantly different from that in the control group (P < 0.05), and carrying the G allele increased the risk of acne. Among the acne patients in Urumqi, the levels of TNF-α, IL-6, IL-1β, and IL-8 showed an upward trend with the increase of acne severity. The frequency of mutant genotypes increased with the aggravation of acne severity, and the difference was statistically significant (P < 0.05), suggesting that gene polymorphism is closely related to the severity of acne. Conclusion: Acne patients in Urumqi are mainly moderate acne, followed by mild acne, and the proportion of severe acne is relatively low. With the increase of acne severity, the levels of inflammatory molecular markers show an upward trend, and gene polymorphism is closely related to the severity of acne.
Keywords
Urumqi; Acne; Clinical phenotype; Inflammatory molecular marker; Susceptibility gene polymorphism; Correlation analysis; Treatment
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How to cite this paper
Correlation Analysis of Clinical Phenotypes, Inflammatory Molecular Markers, and Susceptibility Gene Polymorphisms in Acne Patients in Urumqi and Construction of Treatment Regimens
How to cite this paper: Reyila Mohetaer, Tashkenbaeva Umida. (2026) Correlation Analysis of Clinical Phenotypes, Inflammatory Molecular Markers, and Susceptibility Gene Polymorphisms in Acne Patients in Urumqi and Construction of Treatment Regimens. International Journal of Clinical and Experimental Medicine Research, 10(3), 227-232.
DOI: http://dx.doi.org/10.26855/ijcemr.2026.05.012