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The Evaluation of Liraglutide Combined with Intensive Insulin Therapy on the Pancreatic Beta Cells Function in Type II Diabetes Mellitus

Date: July 22,2021 |Hits: 349 Download PDF How to cite this paper

Shenjiao Dong1, Feixia Shen2,*

1Department of Endocrinology, Taizhou Hospital Affiliated to Wenzhou Medical University, Linhai 317000, Zhejiang, China.

2Department of Endocrinology, The First Affiliated Hospital of Wenzhou Medical University, Wenzhou, Zhejiang 325000, China.

*Corresponding author: Feixia Shen


Objective: The purpose of this study was to analyze the effect of liraglutide administration combined with intensive insulin therapy on the pancreatic β cell function and blood lipid in patients with type 2 diabetes mellitus (T2DM). Methods: The patients with T2DM admitted to our hospital from August 2017 to December 2019 were selected as study subjects. According to the treatments, a total of 200 patients were randomly divided into control group (n = 70) and observation group (n = 130). The patients in the control group were treated with glimepiride combined with intensive insulin therapy. The patients in the observation group were given liraglutide combined with intensive insulin therapy. The changes of body weight and β cell function of patients was compared and analyzed between the two groups. Results: The values of body weight, abdominal circumference and body mass index for patients in the control group revealed no significant difference after treatment compared to non-treatment (P>0.05), but these values in the observation group showed significant decline after treatment (P<0.05). The two groups indicated an obvious decrease on the triglyceride (TG), Total cholesterol (TC), and Low density lipoprotein (LDL), and a significant increase on the high density lipoprotein (HDL) after treatment (P<0.05). In addition, these values in the observation group were superior to that in the control group (P<0.05). There was a decline on the fasting plasma glucose (FPG), glycosylated hemoglobin (HbA1c), and homeostasis model assessment-insulin resistance (HOMA-IR), and a significant increase on the homeostasis model assessment-β (HOMA-β) in both groups after treatment (P<0.05). But these changes were more obviously in the observation group (P<0.05). Conclusion: Liraglutide administration combined with insulin intensive therapy were contributed to improving β cell function, and reducing blood lipid and body weight.


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How to cite this paper

The Evaluation of Liraglutide Combined with Intensive Insulin Therapy on the Pancreatic Beta Cells Function in Type II Diabetes Mellitus

How to cite this paper: Shenjiao Dong, Feixia Shen. (2021) The Evaluation of Liraglutide Combined with Intensive Insulin Therapy on the Pancreatic Beta Cells Function in Type II Diabetes Mellitus. International Journal of Clinical and Experimental Medicine Research5(3), 377-382.

DOI: http://dx.doi.org/10.26855/ijcemr.2021.07.023

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