Abstract
Objective: To investigate the efficacy, observation, and management research of azithromycin for injection combined with ambroxol hydrochloride injection in children with Mycoplasma pneumonia. Methods: A total of 100 children with Mycoplasma pneumonia hospitalized in the Department of Pediatrics from January 2020 to December 2024 were selected, with 50 cases in each group. The two groups were given a low-salt, low-protein diet, and the research group was treated with azithromycin for injection combined with ambroxol hydrochloride injection, while the control group was treated with azithromycin for injection. The treatment period for both groups was 5 days, and both groups received high-quality management during the treatment period. The treatment effects, hospital stay, and adverse reactions of the two groups were observed and compared. After 5 days of treatment in both groups, blood routine tests, hypersensitive CRP, serum procalcitonin, and C-reactive protein were measured in the two groups. Results: After 5 days of treatment, the efficacy of the two groups of children was observed. The total effective rate of treatment in the research group was 94%, which was higher than that of the control group (80%), and the difference was statistically significant (P < 0.05). There were no adverse reactions in both groups. In the 50 children with Mycoplasma pneumonia in the research group, the PCT < 0.08 μg/L, CRP < 6 mg/L, and white blood cell count < 10 × 109/L after treatment were all lower than those of the control group (P < 0.05). The satisfaction, health knowledge mastering score, and hospital stay in the research group were higher than those in the control group (P < 0.05) after treatment and management; the incidence of complications in the research group 7 days after treatment and management was not statistically significant compared to the control group (P > 0.05). Conclusion: The use of azithromycin for injection combined with ambroxol hydrochloride injection in children with Mycoplasma pneumonia has a significant effect. High-quality management intervention during treatment helps to promote the recovery of patients and reduce the level of inflammatory factors, which is worth promoting.
References
[1] Dong AI. Clinical treatment effect of ambroxol hydrochloride injection combined with azithromycin for Mycoplasma pneumonia in children. World Latest Med Inf. 2021;16:761-761.
[2] Chebotareva N, Bobkova I, Neprinzeva N. MP229 heat shock protein 27 and 70 in chronic glomerulonephritis (CGN). Nephrol Dial Transplant. 2017;32:332-338.
[3] Zhu CL, Hu CF, Wang DH et al. Clinical observation of azithromycin for injection combined with benazepril for the treatment of Mycoplasma pneumonia in children. Chin J Pharm Adm. 2016;27:2801-2803.
[4] Su Q. Clinical efficacy and safety evaluation of ambroxol hydrochloride injection combined with yiren huashi granules in the treatment of Mycoplasma pneumonia in children. Chin J Pract Med. 2013;12:132-134.
[5] Wang Y, Yan P, Cheng XH. Clinical observation of 30 cases of children with Mycoplasma pneumonia treated with Shenfu Kang II combined with ambroxol hydrochloride injection. Yunnan J Tradit Chin Med. 2022;36:44-46.
[6] Deng RL, Hu SH, Deng WK. Clinical efficacy and safety evaluation of ambroxol hydrochloride injection combined with yiren jianpi huashi granules in the treatment of Mycoplasma pneumonia in children. Chin J Med Sci. 2022;7:461-463.
[7] Wu DQ. Efficacy analysis of ambroxol hydrochloride injection combined with renin rehabilitation tablets in the treatment of My-coplasma pneumonia in children. Chin Contin Med Educ. 2016;8:134-135.
[8] Li MB, Sun ZM, Ren ZQ et al. Efficacy observation of ambroxol hydrochloride tablets combined with renin rehabilitation tablets in the treatment of proteinuria of Mycoplasma pneumonia in children. Chin J Hosp Drug Eval Anal. 2020;17:75-76.
[9] Kawasaki R, Tashiro Y, Hirata M et al. FP287 comparison of renoprotective effects between short- and long-acting ESA in chronic glomerulonephritis rats. Nephrol Dial Transplant. 2021;31:969-972.
[10] Xiang HX. Clinical efficacy of leflunomide combined with cyclophosphamide in the treatment of severe refractory lupus nephritis patients and its influence on patients’ IgG and CRP. Hebei Med J. 2023;39:915-920.
[11] Wu Y, He Y. The efficacy of renal inflammation recovery tablets combined with ambroxol hydrochloride injection in the treatment of Mycoplasma pneumonia in children and its effects on serum leukotriene 1, tumor necrosis factor-α and interleukin-33. Med Rev. 2022;22:4296-4298.
[12] Luo ZQ, He L. Clinical study of traditional Chinese medicine for invigorating the spleen and nourishing the kidney combined with ambroxol hydrochloride injection in the treatment of proteinuria of Mycoplasma pneumonia in children with spleen-kidney qi deficiency. APJTD. 2022;12:133-135.
[13] Zhou LG, Miao XJ. Efficacy observation of intravenous azithromycin combined with monosialotetrahexosylganglioside sodium in the treatment of hypertensive intracerebral hemorrhage. Mod Drugs Clin. 2021;31:969-972.
How to cite this paper
The Efficacy Observation and Management Study of Azithromycin for Injection Combined with Ambroxol Hydrochloride Injection in the Treatment of Mycoplasma Pneumonia in Children
How to cite this paper: Meijuan Cui. (2026) The Efficacy Observation and Management Study of Azithromycin for Injection Combined with Ambroxol Hydrochloride Injection in the Treatment of Mycoplasma Pneumonia in Children. International Journal of Clinical and Experimental Medicine Research, 10(1), 42-47.
DOI: http://dx.doi.org/10.26855/ijcemr.2026.01.010