magazinelogo

International Journal of Clinical and Experimental Medicine Research

ISSN Online: 2575-7970 ISSN Print: 2575-7989 CODEN: IJCEMH
Frequency: bimonthly Email: ijcemr@hillpublisher.com
Total View: 2465017 Downloads: 553430 Citations: 244 (From Dimensions)
ArticleOpen Access http://dx.doi.org/10.26855/ijcemr.2026.01.008

A Case of Solitary Fibrofolliculoma Over Nasal Bridge in a 46-year-old Woman

Yuze Liu, Qinghua Yang, Biao Yu*

Department of Dermatology, Taihe Hospital, Hubei University of Medicine, Shiyan 442000, Hubei, China.

*Corresponding author: Biao Yu

Published: January 19,2026

Abstract

Fibrofolliculoma is a hallmark clinical manifestation of Birt-Hogg-Dubé syndrome, typically presenting as multiple skin lesions. To date, only 14 cases of solitary fibrofolliculoma have been documented worldwide. Here, we present a case of solitary fibrofolliculoma that is the third recorded to have occurred on the nose. Histopathology showed dilated hair follicles containing keratinous material and follicular epithelium extended out into the fibrotic stroma to rejoin the follicle. The diagnosis of fibrofolliculoma was confirmed by histopathological examination. The patient underwent excision of the lesion and local advancement of the skin flap. Here, we report typical clinical and histopathological findings in solitary Fibrofolliculoma. This report details the typical clinical features and histopathological findings of solitary fibrofolliculoma, contributing to the limited literature on this rare entity.

Keywords

Solitary fibrofolliculoma; nasal tumor; folliculin

References

[1] Birt AR, Hogg GR, Dube WJ. Hereditary multiple fibrofolliculomas with trichodiscomas and acrochordons. Arch Dermatol. 1977;113:1674-7.

[2] Scully K, Bargman H, Assaad D. Solitary fibrofolliculoma. J Am Acad Dermatol. 1984;11:361-3.

[3] Wang W, Cheng J. Solitary fibrofolliculoma of the upper eyelid in a 68-year old female: a case report. BMC Ophthalmol. 2020;20.

[4] Tellechea O, Cardoso JC, Reis JP, et al. Benign follicular tumors. An Bras Dermatol. 2015;90:780-96.

[5] César A, Baudrier T, Mota A, et al. A case of Birt-Hogg-Dubé syndrome presenting with a single pedunculated fibrofolliculoma and a novel FLCN gene mutation. Actas Dermosifiliogr. 2016;107:541-3.

[6] Chang JK, Lee DC, Chang MH. A solitary fibrofolliculoma in the eyelid. Korean J Ophthalmol. 2007;21:169-71.

[7] Cho E, Lee JD, Cho SH. A solitary fibrofolliculoma on the concha of the ear. Int J Dermatol. 2012;51:616-7.

[8] Al-Refu K. Stem cells and alopecia: a review of pathogenesis. Br J Dermatol. 2012;167:479-84.

[9] Misago N, Kimura T, Narisawa Y. Fibrofolliculoma/trichodiscoma and fibrous papule (perifollicular fibroma/angiofibroma): a revaluation of the histopathological and immunohistochemical features. J Cutan Pathol. 2009;36:943-51.

[10] Tong Z, Yin Z. Distribution, contribution and regulation of nestin(+) cells. J Adv Res. 2023.

[11] Criscito MC, Mu EW, Meehan SA, et al. Dermoscopic features of a solitary fibrofolliculoma on the left cheek. J Am Acad Dermatol. 2017;76:S8-9.

[12] Jfri A, Najera L, Cembrero H, et al. Sonography of solitary fibrofolliculoma with histologic correlation. J Ultrasound. 2020;24:359-60.

[13] Rosales-Duran S, Ricaurte-Jiménez M, Ferreira PS, et al. In Vivo Reflectance Confocal Microscopy of Adnexal Tumors: Evalua-tion of Trichoepithelioma, Sebaceoma, and Fibrofolliculoma. Am J Dermatopathol. 2022;44:190-5.

[14] Gambichler T, Wolter M, Altmeyer P, et al. Treatment of Birt-Hogg-Dubé syndrome with erbium:YAG laser. J Am Acad Dermatol. 2000;43:856-8.

[15] Cogrel O. Fibrofolliculomes et tumeurs cutanées du syndrome de Birt-Hogg-Dubé traitées par laser CO2. Ann Dermatol Venereol. 2016;143:230-2.

[16] Pritchard SE, Mahmoudizad R, Parekh PK. Successful treatment of facial papules with electrodessication in a patient with birt-hogg-dubé syndrome. Dermatol Online J. 2014;20.

[17] Gijezen LM, Vernooij M, Martens H, et al. Topical rapamycin as a treatment for fibrofolliculomas in Birt-Hogg-Dube syndrome: a double-blind placebo-controlled randomized split-face trial. PLoS One. 2014;9:e99071.

[18] Starink TM, Brownstein MH. Fibrofolliculoma: solitary and multiple types. J Am Acad Dermatol. 1987;17:493-6.

[19] Hong JK, Yoon DH, Kim TY, Kim HO, et al. A case of solitary fibrofolliculoma. Ann Dermatol. 1997;9:286-8.

[20] Cesinaro AM, Rusev BC, Kutzner H. Fibrofolliculoma with ancient/pseudosarcomatous features. J Cutan Pathol. 2010;37:987-90.

[21] Sohn KM, Woo YJ, Kim JE, et al. A solitary nodule on the posterior pinna. Indian J Dermatol Venereol Leprol. 2019;85:111-3.

[22] Mishra DK, Jakati S, Kaliki S. Solitary fibrofolliculoma of the eyelid: A less known entity. Indian J Pathol Microbiol. 2021;64: 195-6.

How to cite this paper

A Case of Solitary Fibrofolliculoma Over Nasal Bridge in a 46-year-old Woman

How to cite this paper: Yuze Liu, Qinghua Yang, Biao Yu. (2026) A Case of Solitary Fibrofolliculoma Over Nasal Bridge in a 46-year-old Woman. International Journal of Clinical and Experimental Medicine Research10(1), 33-37.

DOI: http://dx.doi.org/10.26855/ijcemr.2026.01.008