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International Journal of Systems Biology and Bioinformatics

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ArticleOpen Access http://dx.doi.org/10.26855/ijsbb.2025.12.002

Research Progress on the Correlation Between CYP19A1 Gene Single Nucleotide Polymorphism and Growth Hormone

Huanxi Wang, Aiping Wang*

Kunming First People's Hospital, Yunan 650011, Kunming, China.

*Corresponding author: Aiping Wang

Published: November 26,2025

Abstract

CYP19A1 gene encodes an important enzyme - aromatase, which is a key enzyme in the process of estrogen synthesis. The variation of the CYP19A1 gene can change the aromatase activity encoded by it, thus affecting the level of estrogen. In recent years, the single nucleotide polymorphism of the CYP19A1 gene has become one of the hot issues in research. Growth hormones play an important role in human growth and development. Growth hormone deficiency caused by complete or partial lack of growth hormone is a common endocrine disease that affects children's height and leads to children's shortness. Its incidence is increasing year by year in China. Studies have shown that CYP19A1 gene SNP There is a correlation between height variation and growth hormone levels. This article will review the research progress of the correlation between CYP19A1 gene polymorphism and growth hormone based on the current research results.

Keywords

CYP19A1 gene; Single nucleotide polymorphism; Growth hormones

References

[1] Chang GY. Research progress on aromatase and its related genes in children's growth and development. Int J Pediatr. 2010;37(3):3.

[2] Deberles E, Durand I, Mittre H, et al. Local aromatase excess with recruitment of unusual promoters of CYP19A1 gene in prepubertal patients with gynecomastia. J Pediatr Endocrinol Metab. 2022;35(7):924-30.

[3] Rui WL. Association between single nucleotide polymorphisms of CYP19A1 gene and CAG repeat sequences of AR gene with female pattern baldness in Han Chinese population [dissertation]. Shanghai: Fudan University; 2014.

[4] Liu Y. Association between single nucleotide polymorphisms of CYP19a1 gene and acne vulgaris in Han Chinese adults [dissertation]. Shanghai: Fudan University; 2012.

[5] Zhang DJ, Yuan WX, Ma LN, et al. Single nucleotide polymorphisms associated with ovulation disorders in polycystic ovary syndrome. Chin J Eugenics Genet. 2023;31(4):871-5.

[6] Wang SR, Tuoya. Research progress on gene polymorphism in endometriosis. J Med Postgrad. 2020;33(2):206-9.

[7] Liu FY. Effects of single nucleotide polymorphisms in genes such as CYP19A1 on lipid changes in postmenopausal breast cancer patients induced by nonsteroidal aromatase inhibitors [dissertation]. Beijing: Med Coll Chin PLA; 2019.

[8] Association analyzes of CYP19 gene polymorphisms with height variation in a large sample of Caucasian nuclear families. Hum Genet. 2006;120(1):119-25.

[9] Sun X, Zhu SQ. Structure and function of growth hormone. Foreign Med Sci (Physiol Pathol Clin Sci). 1999;(1):6-9.

[10] Ma HJ, Fu SC, Xiao A, et al. The associations of CYP19A1 rs700518 polymorphism with bone mineral density and risk of osteoporosis: a meta-analysis. Gynecol Endocrinol. 2020;36(7):626-31.

[11] Hawton K, Walton-Betancourth S, Rumsby G, et al. Growth Hormone With Aromatase Inhibitor May Improve Height in CYP11B1 Congenital Adrenal Hyperplasia. Pediatrics. 2017;139(2).

[12] Wang X, Liang Y, Liu Q, et al. Association of CYP19A1 Gene, Plasma Zinc, and Urinary Zinc with the Risk of Type 2 Diabetes Mellitus in a Chinese Population. Biol Trace Elem Res. 2023;201(9):4205-15.

[13] Ma JT, Zhang SZ, Yang CL, et al. Expression and significance of aromatase P450 and estrogen receptor at the endometrial-myometrial interface and lesions in adenomyosis. Chin J Matern Child Health. 2018;33(15):3529-32.

[14] Yenuganti VR, Ravinder, Singh D. Endotoxin induced TLR4 signaling downregulates CYP19A1 expression through CEBPB in buffalo granulosa cells. Toxicol In Vitro. 2017;42:93-100.

[15] Parween S, DiNardo G, Baj F, et al. Differential effects of variations in human P450 oxidoreductase on the aromatase activity of CYP19A1 polymorphisms R264C and R264H. J Steroid Biochem Mol Biol. 2020;196:105507.

[16] Cai Y, Diao HD. Analysis of the relationship between serum TGF-β1, Apelin, CYP19A1 levels and PCOS endocrine abnormalities. J Reprod Med. 2022;31(4):463-7.

[17] Kor Y. Central precocious puberty in a case of late-diagnosed familial testotoxicosis and long-term treatment monitoring. Hormones (Athens). 2018;17(2):275-8.

[18] Shi XJ. Research progress on endometriosis and aromatase P450, estrogen receptor and its subtypes. China Med Guide. 2012;10(9):389-90.

[19] Bulun SE, Sebastian S, Takayama K, et al. The human CYP19 (aromatase P450) gene: update on physiologic roles and genomic organization of promoters. J Steroid Biochem Mol Biol. 2003;86(3-5):219-24.

Copyright

© 2025 by the author(s).
This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution-NonCommercial-NoDerivatives (CC BY-NC-ND) license, which permits non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited and is not modified or adapted.
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How to cite this paper

Research Progress on the Correlation Between CYP19A1 Gene Single Nucleotide Polymorphism and Growth Hormone

How to cite this paper: Huanxi Wang, Aiping Wang. (2025). Research Progress on the Correlation Between CYP19A1 Gene Single Nucleotide Polymorphism and Growth Hormone. International Journal of Systems Biology and Bioinformatics1(1), 4-8.

DOI: http://dx.doi.org/10.26855/ijsbb.2025.12.002