ArticleOpen Access http://dx.doi.org/10.26855/ijabc.2025.12.001
Factors Influencing Neuromotor Function Assessment in Mice: mNSS and Grid Walk Tests
Xiaohui Li
Guangdong Country Garden School, Country Garden, Beijiao Town, Shunde, Foshan 528312, Guangdong, China.
*Corresponding author: Xiaohui Li
Published: November 14,2025
Abstract
This study aims to evaluate the motor capacity of mice using standardized assessment methods, highlighting the influence of individual differences such as age, weight, and gender. The motor abilities of both male and female mice were comprehensively assessed by applying two behavioural tests—the Modified Neurological Severity Score (mNSS) and the Grid Walk test. The results indicated that age and weight were the primary factors affecting physical performance, while gender played a minor role. Furthermore, this study underscores the importance of considering additional variables, even under standardized testing conditions, as they may influence the outcomes of mNSS and Grid Walk assessments. Possible strategies to enhance the reliability and reproducibility of these behavioral tests are also discussed.
Keywords
Neurodegenerative diseases; mNSS; mice; genders; age
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How to cite this paper
Factors Influencing Neuromotor Function Assessment in Mice: mNSS and Grid Walk Tests
How to cite this paper: Xiaohui Li. (2025) Factors Influencing Neuromotor Function Assessment in Mice: mNSS and Grid Walk Tests. International Journal of Animal Behavior and Cognition, 1(1), 1-5.
DOI: http://dx.doi.org/10.26855/ijabc.2025.12.001