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International Journal of Clinical and Experimental Medicine Research

ISSN Print: 2575-7989 Downloads: 528888 Total View: 4535717
Frequency: bimonthly ISSN Online: 2575-7970 CODEN: IJCEMH
Email: ijcemr@hillpublisher.com Citations: 244
ArticleOpen Access http://dx.doi.org/10.26855/ijcemr.2025.11.001

Factors Influencing Persistent High-risk HPV Infection in Chinese Women: A Systematic Review and Meta-analysis

Hailing You#, Shuhua Fu#, Yuan Chen*

Shenzhen Hospital of Beijing University of Chinese Medicine, Shenzhen 518172, Guangdong, China.

#These authors contributed equally to this work and should be considered co-first authors.

*Corresponding author: Yuan Chen

Published: November 13,2025

Abstract

Objective: To investigate the risk factors of persistent Human papillomavirus (HPV) infection in Chinese women. Methods: The CNKI, Wanfang, VIP, CN journals, PubMed, Embase, and Cochrane Library databases were searched, and a total of 13 published studies related to high-risk Human papillomavirus (HPV) susceptibility in Chinese women were collected. The 13 included studies were organized, counted, and analyzed individually. Results: After meta-analysis, the risk factors for persistent infection of high-risk HPV in Chinese women were identified as follows: age > 30 years, education in high school or below, age at first sexual life ≤20 years, number of sexual partners > 1, history of cervical disease or family history, and number of pregnancies > 2. Conclusion: The main risk factors for persistent infection of high-risk HPV in Chinese women are old age, low education, age of first sexual life ≤20 years, number of sexual partners > 1, personal history of cervical disease or family history, and number of pregnancies > 2.

Keywords

Human papillomavirus infection; High-risk subtypes; Predisposing factor

References

[1] Fang Y, Guo X, Tong S, Ma Y. Risk factors for high-risk human papillomavirus infection and its impact on vaginal microecological environment. Chin J Obstet Gynecol. 2024;25:4-7.

[2] Chen J, Ma C, Tan Y, Lü Y, Wang Q. Current situation and risk factors of HPV infection in women seeking medical attention in Laiwu area. Chin J Nosocomiol. 2023;33:3625-9.

[3] Li J, Zhang L, He Y, Li Y. Analysis of HPV infection screening in women undergoing health examinations and discussion of susceptible factors and intervention measures. J Mod Med Health Res. 2023;7:110-3.

[4] Li H, Hou N, Zhang J, Wang L, Liu X, Gao Y, et al. Investigation and analysis of HPV infection status and risk factors in female workers of a coal mine. Ind Health Occup Dis. 2023;49:389-93.

[5] Xiao C, Li S. Analysis of risk factors for high-risk human papillomavirus infection and construction of a line chart prediction model. Lab Med Clin. 2023;20:2473-6.

[6] Song H, Zhao Z, Qin F, Wang L, Zhao J, Qin W, et al. Analysis of risk factors for HPV infection in women visiting the gynecological outpatient clinic and survey on HPV vaccine awareness. Med Forum Mag. 2023;44:54-7, 61.

[7] Qiao L, Fan L, Liu X, Liu X, Zhang H, Li J, et al. Analysis of high-risk human papillomavirus infection and related risk factors in some women in Shijiazhuang area. Matern Child Health Care China. 2021;36:3771-4.

[8] Yang Y, Qin M, Lin C, Xie G. Investigation and analysis of HPV genotyping in 1569 women and high-risk factors. Med Theory Pract. 2020;33:150-2.

[9] Shi N, Lu Q, Zhang J, Li L, Zhang J, Zhang F, et al. Analysis of risk factors for persistent infection of asymptomatic women with high-risk human papilloma virus. Hum Vaccin Immunother. 2017;13(1):1-7.

[10] Qiao Y, Wang A, Fang L, Wang L. Incidence of persistent and high-risk human papillomavirus infection and associated factors among HIV-positive women in China, 2015-2016. Clin Obstet Gynecol (Engl Ed). 2021;1:130-7.

[11] Shi R, Qi W, Cai J, Zhao M, Wang Z. Independent risk factors for high-risk human papillomavirus infection among rural women in Shanxi Province, China: A population-based, case-control study. Arch Gynecol Obstet. 2023;308(2):551-9.

[12] Niu J, Pan S, Wei Y, Hong Z, Gu L, Di W, et al. Epidemiology and analysis of potential risk factors of high-risk human papillo-mavirus (HPV) in Shanghai, China: a cross-sectional one-year study in non-vaccinated women. J Med Virol. 2022;94(2):761-70.

[13] Su Y, Yuan Z, Xu C, Li Z, Zhu R, Zhang W, et al. Prevalence and genotype distribution of human papillomavirus infection among women: a population-based study in Dali Bai Autonomous Prefecture, Yunnan Province, China. J Med Virol. 2019;91(9):1553-61.

How to cite this paper

Factors Influencing Persistent High-risk HPV Infection in Chinese Women: A Systematic Review and Meta-analysis

How to cite this paper: Hailing You, Shuhua Fu, Yuan Chen. (2025) Factors Influencing Persistent High-risk HPV Infection in Chinese Women: A Systematic Review and Meta-analysis. International Journal of Clinical and Experimental Medicine Research9(6), 582-587.

DOI: http://dx.doi.org/10.26855/ijcemr.2025.11.001