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International Journal of Clinical and Experimental Medicine Research

ISSN Print: 2575-7989 Downloads: 528885 Total View: 4535667
Frequency: bimonthly ISSN Online: 2575-7970 CODEN: IJCEMH
Email: ijcemr@hillpublisher.com Citations: 244
ArticleOpen Access http://dx.doi.org/10.26855/ijcemr.2025.09.014

Evaluation of the Effect of Radiotherapy Combined with Immunotherapy on the Local Control Rate in Patients with Hepatocellular Carcinoma and Portal Vein Tumor Thrombosis

Jiaxin Li

The First Affiliated Hospital of Sun Yat sen University, Guangzhou 510080, Guangdong, China.

*Corresponding author: Jiaxin Li

Published: October 23,2025

Abstract

Objective: To evaluate the effect of radiotherapy combined with immunotherapy on the local control rate in patients with hepatocellular carcinoma and portal vein tumor thrombus. Methods: A total of 60 patients with hepatocellular carcinoma complicated by portal vein tumor thrombus were selected from The Cancer Genome Atlas (TCGA) Database between April 2024 and April 2025. These patients were randomly divided into an observation group (Radiotherapy combined with immunotherapy) and a control group (Radiotherapy alone), with 30 patients in each group. The local control rate and other related indicators were compared between the two groups. Results: The local control rate in the observation group was 70% (21/30), significantly higher than that in the control group (40% (12/30), with a statistically significant difference (P < 0.05). The median progression-free survival in the observation group was 8 months, longer than that in the control group (5 months). Conclusion: Radiotherapy combined with immunotherapy improves the local control rate and prolongs progression-free survival in patients with hepatocellular carcinoma and portal vein tumor thrombus, making it an effective treatment option.

Keywords

Hepatocellular carcinoma; Portal vein tumor thrombus; Radiotherapy; Immunotherapy; Local control rate

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How to cite this paper

Evaluation of the Effect of Radiotherapy Combined with Immunotherapy on the Local Control Rate in Patients with Hepatocellular Carcinoma and Portal Vein Tumor Thrombosis

How to cite this paper: Jiaxin Li. (2025) Evaluation of the Effect of Radiotherapy Combined with Immunotherapy on the Local Control Rate in Patients with Hepatocellular Carcinoma and Portal Vein Tumor Thrombosis. International Journal of Clinical and Experimental Medicine Research9(5), 571-576.

DOI: http://dx.doi.org/10.26855/ijcemr.2025.09.014