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International Journal of Clinical and Experimental Medicine Research

ISSN Print: 2575-7989 Downloads: 204322 Total View: 2406420
Frequency: quarterly ISSN Online: 2575-7970 CODEN: IJCEMH
Email: ijcemr@hillpublisher.com
Article Open Access http://dx.doi.org/10.26855/ijcemr.2024.10.004

Analysis of Expression and Prognosis Value for Matrix Metalloproteinases in Human Colorectal Carcinoma

Ping Li1, Sijin Li1, Xing Zhao3, Yajie Dong4, He Song1, Hairu Ji2, Peiyuan He1,*, Zhiping Hou2,*

1Department of Gastroenterology, The Affiliated Hospital of Chengde Medical University, Chengde 067400, Hebei, China.

2Department of Pathology, Chengde Medical University, Chengde 067050, Hebei, China.

3Department of Pathology, The Affiliated Hospital of Chengde Medical University, Chengde 067400, Hebei, China.

4Department of Pathophysiology, Chengde Medical University, Chengde 067050, Hebei, China.

*Corresponding author: Peiyuan He, Zhiping Hou

Published: November 13,2024

Abstract

Background: Matrix metalloproteinases (MMPs), a family of endogenous proteases are implicated in the progression of several cancer types. Previous studies report that MMPs participate in tumorigenesis of colorectal cancer. However, the aberrant expression of MMP members and their roles in the prognosis of colorectal cancer has not been explored. Methods: This study sought to explore differentially expressed genes and compared the transcriptional expression with survival data of MMPs in colorectal cancer (CRC) samples using Oncomine, cBioPortal databases, GEPIA (Gene Expression Profiling Interactive Analysis), and Kaplan-Meier Plotter online tools. Results: MMP1,3,7,9,11,12 and 28 showed high expression levels in CRC tissues, but only expression of MMP11 and 12 were correlated with advanced tumor stages. Conclusion: The findings of this study show that MMP1,3,7,9,11 and 28 are potential targets for the effective treatment of individuals with CRC, while MMP9 and 12 are promising novel prognostic signatures of CRC.

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How to cite this paper

Analysis of Expression and Prognosis Value for Matrix Metalloproteinases in Human Colorectal Carcinoma

How to cite this paper: Ping Li, Sijin Li, Xing Zhao, Yajie Dong, He Song, Hairu Ji, Peiyuan He, Zhiping Hou. (2024) Analysis of Expression and Prognosis Value for Matrix Metalloproteinases in Human Colorectal Carcinoma. International Journal of Clinical and Experimental Medicine Research8(4), 547-563.

DOI: http://dx.doi.org/10.26855/ijcemr.2024.10.004