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International Journal of Clinical and Experimental Medicine Research

ISSN Online: 2575-7970 ISSN Print: 2575-7989 CODEN: IJCEMH
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ArticleOpen Access http://dx.doi.org/10.26855/ijcemr.2023.10.021

The Association Between IL-1beta and Intractable Epilepsy: Meta-analysis

Ruizhen Huo*, Yun Chen

Guangxi Medical University, Nanning, Guangxi, China.

*Corresponding author: Ruizhen Huo

Published: November 30,2023

Abstract

Objective: To systematically evaluate the relationship between IL-1 and refractory epilepsy and its diagnostic value. Methods: The database was searched in PubMed, The Cochrane Library, Web of Science and other data-bases. The language was English. The time limit was from the establishment of the database to the relevant literature on January 10, 2023. Stata 15.1 software was used for specificity, sensitivity, publication bias, meta-regression analysis and heterogeneity test for specificity to analyze the relationship between IL-1 and refractory epilepsy and its diagnostic value. Results: N articles were included in the study. The meta-analysis showed that the heterogeneity of the study was N% (95% CI: N1, N2), P <0.05. According to the meta-regression analysis, the sample collection site is the main source of heterogeneity of the meta-analysis. The Stata funnel plot and egger results (p = 0.278) indicate that there may be some publication bias in the included literature. The main source is the clinical study results of the treatment-non-treatment subgroup. Conclusion: IL-1 as an inflammatory factor has a positive correlation with refractory epilepsy, but its specificity is not high. In the future, a large number of basic and clinical studies are needed to prove that IL-1 affects the inflammatory pathways and other inflammatory factors affected by refractory epilepsy, and provides new ideas for the treatment of refractory epilepsy.

Keywords

Refractory epilepsy, IL-1β

References

[1] Hauser WA, Beghi E. First seizure definitions and worldwide incidence and mortality [J]. Epilepsia, 2008;49(suppl 1):8-12. 

[2] Hauser WA. Status Epilepticus: epildemiologic considerations [J]. Neurology, 1990, 40(Supp12): 9-13. 

[3] Savage TE, Sourbron J, Bruno PL, et al. Efficacy of cannabidiol in subjects with refractory epilepsy relative to concomitant use of clobazam. Epilepsy Res 2019; 160:106263. DOI:10.1016/j.eplepsyres.2019.106263.

[4] Vezzani A, Balosso S, Ravizza T. Inflammation and epilepsy [J]. Handb Clin Neurol, 2012, 107: 163-175. 

[5] Vezzani A, French J, Bartfai T, et al. The role of inflammation inepilepsy [J]. Nat Rev Neurol, 2011, 7: 31-40.

[6] Choi, J. Min, H. J. Shin, J. Increased levels of HMGB1 and pro-inflammatory cytokines in children with febrile seizures 1743-2094. DOI:10.1186/1742-2094-8-135.

[7] Feng, Z. H. Hao, J. W. Ye, L. Dayao, C. Yan, N. Yan, Y. Chu, L. Shi, F. D. Overexpression of mu-calpain in the anterior temporal neocortex of patients with intractable epilepsy correlates with clinicopathological characteristics 1059-1311 DOI:10.1016/j.seizure.2011.01.010.

[8] Dundar, N. O. Aktekin, B. Ekinci, N. C. Sahinturk, D. Yavuzer, U. Yegin, O. Haspolat, S.  Interleukin-1beta secretion in hippo-campal sclerosis patients with mesial temporal lobe epilepsy 2035-8385. DOI:10.4081/ni.2013.e17.

[9] Pollard, J. R. Eidelman, O. Mueller, G. P. Dalgard, C. L. Crino, P. B. Anderson, C. T. Brand, E. J. Burakgazi, E. Ivaturi, S. K. Pollard, H. The TARC/sICAM5 ratio in patient plasma is a candidate biomarker for drug-resistant epilepsy 1664-2295. DOI:10.3389/fneur.2012.00181.

[10] Bartolini, L. Piras, E. Sullivan, K. Gillen, S. Bumbut, A. Lin, C. T. Leibovitch, E. C. Graves, J. S. Waubant, E. L. Chamberlain, J. M. Gaillard, W. D. Jacobson, S. Detection of HHV-6 and EBV and Cytokine Levels in Saliva From Children With Seizures: Results of a Multi-Center Cross-Sectional Study. 1664-2295. DOI:10.3389/fneur.2018.00834.

[11] Pedre, L. L. Chacon, L. M. M. Fuentes, N. P. Agramonte, M. D. R. Sanchez, T. S. Cruz-Xenes, R. M. Hung, M. L. D. Diaz, B. E. Martin, M. M. B. Orozco-Suarez, S. Follow-Up of Peripheral IL-1 and IL-6 and Relation with Apoptotic Death in Drug-Resistant Temporal Lobe Epilepsy Patients Submitted to Surgery. 2076-328X. DOI:10.3390/bs8020021.

[12] Farias-Moeller, R. LaFrance-Corey, R. Bartolini, L. Wells, E. M. Baker, M. Doslea, A. Suslovic, W. Greenberg, J. Carpenter, J. L. Howe, C. L. Fueling the FIRES: Hemophagocytic lymphohistiocytosis in febrile infection-related epilepsy syndrome 0013-9580. DOI:10.1111/epi.14524.

[13] Pollandt S. Thermoregulation in epilepsy. Handb Clin Neurol 2018;157:737-747.DOI:10.1016/B978-0-444-64074-1.00045-8.

[14] Terrone G, Frigerio F, Balosso S, et al. Inflammation and reactive oxygen species in status epilepticus: Biomarkers and implications for therapy. Epilepsy Behav 2019; 106275. DOI:10.1016/j.yebeh.2019.04.028.

[15] van Vliet EA, Aronica E, Vezzani A. Review: Neuroinflammatory pathways as treatment targets and biomarker candidates in epilepsy: emerging evidence from preclinical and clinical studies. Neuropathol Appl Neurobiol 2018; 44:91-111.

DOI:10.1111/nan.12444.

[16] Pressler RM. Why we urgently need improved seizure and epilepsy therapies for children and neonates. Neuropharmacology 2019; 107854. DOI:10.1016/j.neuropharm.2019.107854.

How to cite this paper

The Association Between IL-1beta and Intractable Epilepsy: Meta-analysis

How to cite this paper: Ruizhen Huo, Yun Chen. (2023) The Association Between IL-1beta and Intractable Epilepsy: Meta-analysis. International Journal of Clinical and Experimental Medicine Research7(4), 634-640.

DOI: http://dx.doi.org/10.26855/ijcemr.2023.10.021