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International Journal of Clinical and Experimental Medicine Research

ISSN Online: 2575-7970 ISSN Print: 2575-7989 CODEN: IJCEMH
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ArticleOpen Access http://dx.doi.org/10.26855/ijcemr.2023.07.028

Relationship between Rad23 Overexpression and Tau NFT Buildup in Alzheimer’s Disease

Roy Rao

Vanderbilt University, Nashville, Tennessee, USA.

*Corresponding author: Roy Rao

Published: August 21,2023

Abstract

This paper seeks to analyze the results of a Drosophila melanogaster highthroughput sequencing experiment to understand the role of AICD protein overexpression in Alzheimer’s Disease. Of particular interest was Rad23, a nucleotide excision repair and protein shuttling gene upregulated with AICD overexpression. Analysis of these results and existing literature indicated a possible link between Rad23 overexpression and the buildup of Tau neurofibrillary tangles in the brains of Alzheimer’s Disease patients. Rad23 has a role in the degradation of proteins; it is thought to shuttle polyubiquitinated proteins to the proteasome. Rad23 binds more effectively to K48 than to other lysine residues, and K48 residues are primarily responsible for marking proteins for degradation. However, overexpression of Rad23 leads to the inhibition of proteolysis, thought to be a product of competition between polyubiquitinated substrate binding to Rad23 and to the proteasome. This paper proposes a possible mechanism through which Rad23 overexpression inhibits the proteolysis of Tau neurofibrillary tangles, causing the development of Alzheimer’s Disease.

Keywords

Rad23, Tau NFT, Alzheimer

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How to cite this paper

Relationship between Rad23 Overexpression and Tau NFT Buildup in Alzheimer’s Disease

How to cite this paper: Roy Rao. (2023) Relationship between Rad23 Overexpression and Tau NFT Buildup in Alzheimer’s Disease. International Journal of Clinical and Experimental Medicine Research7(3), 457-461.

DOI: http://dx.doi.org/10.26855/ijcemr.2023.07.028