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International Journal of Clinical and Experimental Medicine Research

ISSN Online: 2575-7970 ISSN Print: 2575-7989 CODEN: IJCEMH
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ArticleOpen Access http://dx.doi.org/10.26855/ijcemr.2023.07.011

Associations (Correlations) Between Serum Mucin1 and CETP Status in Bangladeshi Patients with Cholelithiasis and Effects of Laparoscopic Cholecystectomy on the Status

A. S. M. Giasuddin1,*, K. A. Jhuma2, M. A. M. Choudhury3, A. M. M. Haq4

1Senior Consultant in Laboratory Medicine (Biochemistry & Immunology) and Founder Director, Impulse Hospital, ImHS&RCLtd, 304/E, Tejgaon Industrial Area, Dhaka-1208, Bangladesh.

2Professor of Biochemistry and Head at Dhaka Medical College, Dhaka-1000, Bangladesh.

3Professor of Surgery, Department of Surgery, MCW&H, MHWT, Plot-4, Road-8/9, Sector-1, Uttara Model Town, Dhaka-1230, Bangladesh.

4Honorary Professor of Medicine, Department of Internal Medicine, MCW&H and Chairman of MRU, MCN&H, MHWT, Uttara, Dhaka-1230, Bangladesh.

*Corresponding author: A. S. M. Giasuddin

Published: August 11,2023

Abstract

Objective: To evaluate associations of Mucin1 and cholesterol ester transfer protein (CETP) status between normal control subjects (NCs) and Cholelithiasis i.e. gallstone disease (GSD) patients (Pts) preoperatively (I0) and postoperatively (II0) with laparoscopic cholecystectomy. Patients and Methods: Adult Pts (N=55, Gender: 10 males, 45 females; Age range: 25-65 years, Mean age±SD: 45.5±12.2 years) were those reported in our previous case-control prospective interventional studies carried out from October 2016 to March 2018 at MRU, MHWT, Uttara, Dhaka, Bangladesh. The patients with GD were those diagnosed according to standard clinical and laboratory criteria and reported in our previous publications. The lipid profile (TG, TC, LDL-C, HDL-C), Lp (a), ApoA1, ApoB100, ApoE, Mucin1 and CETP status in serum of NCs and Pts (I0, II0) and Pts-Bile (I0) were made by standard clinical laboratory methods using research/diagnostics kits from reputed companies and reported in the recent past. Recently, further advanced statistical analyses on these data were made according to the objectives of the present article i.e. to obtain information regarding associations (correlations) between serum Mucin1 and CEPT status among NCs and Pts (I0, II0) by using SPSS programme-version 26. Results: Regarding associations (correlations) between Mucin1 and CETP status among NCs (I0) and Pts (I0) and Pts (II0), significant Pearson correlations were found for Pts-Mucin1 (I0) vs Pts-CETP (I0) (r=0.316, p=0.019), Pts-Mucin1 (Bile-I0) vs Pts-CETP (Bile-I0) (r=0.441, p=0.005), Pts-Mucin1 (II0) vs Pts-CETP (I0) (r=0.398, p=0.007), Pts-Mucin1 (I0) vs Pts-CETP (II0) (r=0.335, p=0.017) and NCs-Mucin1 (I0) vs Pts-CETP (Bile-10) (r=0.375, p=0.048). No significant correlations were observed between any of the other groups compared (P>0.05). Conclusions: The observations on associations between Mucin1 and CETP among NCs and Pts (I0, II0) suggested their probable involvements in the aetiopathogenesis of the disease. The results were discussed in the light of recent knowledge available for altered Mucin1 and CETP status and complex molecular processes in the pathogenesis of the disease GSD.

Keywords

Mucin1, CETP, Cholelithiasis, Gallstone disease, Laparoscopic cholecystectomy

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How to cite this paper

Associations (Correlations)  Between Serum Mucin1 and CETP Status in Bangladeshi Patients with Cholelithiasis and Effects of Laparoscopic Cholecystectomy on the Status

How to cite this paper: A. S. M. Giasuddin, K. A. Jhuma, M. A. M. Choudhury, A. M. M. Haq. (2023) Associations (Correlations) Between Serum Mucin1 and CETP Status in Bangladeshi Patients with Cholelithiasis and Effects of Laparoscopic Cholecystectomy on the Status. International Journal of Clinical and Experimental Medicine Research, 7(3), 356-361.

DOI: http://dx.doi.org/10.26855/ijcemr.2023.07.011

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