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International Journal of Clinical and Experimental Medicine Research

ISSN Online: 2575-7970 ISSN Print: 2575-7989 CODEN: IJCEMH
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ArticleOpen Access http://dx.doi.org/10.26855/ijcemr.2023.07.005

Secondary Malignancies among Myeloproliferative Neoplasms

Eren Arslan Davulcu

Hematology Clinic, University of Health Sciences Bakırkoy Dr. Sadi Knuk Training and Research Hospital, Istanbul, Turkey.

*Corresponding author: Eren Arslan Davulcu

Published: August 8,2023

Abstract

Aim: The frequency of secondary cancers has increased in myeloproliferative   neoplasms (MPN) compared to the general population. The association of MPN and secondary cancer has a negative effect on the patient's survival. This study aims to retrospectively evaluate secondary cancers that developed during the diagnosis and follow-up of patients with MPN. Materials and Methods: Patients diagnosed with MPN between 2000 and 2019 were retrospectively evaluated. Patients who developed secondary cancer simultaneously with the diagnosis of MPN or during the follow-up period were examined. Their clinical characteristics, treatment details, progression, death, and toxicities for both diseases were analyzed. Results: Among 328 MPN patients, 9 of them had secondary malignancies. The most common malignancies were squamous cell carcinoma of the skin (1%), and breast invasive ductal carcinoma (1%). The median time between the diagnosis of MPN and the development of secondary malignancy was 60 (range 0-144) months. The median follow-up was 100 (range 1-161) months. All patients were alive as of the end of the study. Conclusion: It is important to be aware of the increased incidence of secondary cancers in MPN patients. This study showed that in MPN patients with secondary cancer, the treatment of both diseases can be performed simultaneously without a life-threatening problem and without hindering the treatment of the diseases. The possibilities for advanced diagnosis in both hematological and solid malignancies are constantly increasing, and our knowledge at the molecular level is expanding. This knowledge can create targeted treatment possibilities in the management of both diseases separately or together.

Keywords

Myeloproliferative neoplasms, secondary cancer, treatment

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How to cite this paper

Secondary Malignancies among Myeloproliferative Neoplasms

How to cite this paper:  Eren Arslan Davulcu. (2023) Secondary Malignancies among Myeloproliferative Neoplasms. International Journal of Clinical and Experimental Medicine Research7(3), 326-329.

DOI: http://dx.doi.org/10.26855/ijcemr.2023.07.005