Advance in Biological Research

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Study of the Influence of a New Phytocomposition on Various Phases of Aseptic Inflammation

Z. Z. Khakimov1, A. U. Babazhanov2, A. Kh Rakhmanov1,*, L. I. Tursunova3, U. A. Khadzhieva3

1Tashkent Medical Academy, Tashkent, Uzbekistan. 

2Urgench Branch of the Tashkent Medical Academy, Urgench, Uzbekistan.

3Uzbek Research Chemical-Pharmaceutical Institute named after A. Sultanov, Uzbekistan.

*Corresponding author: A. Kh Rakhmanov

Published: August 1,2023


It was found that the phytocomposition "Dorusim" helps to eliminate all phases of the multicomponent inflammation process in experimental studies conducted on mature white male rats. So, the development of a chemical burn - the process of alteration is not eliminated during the first month of observation in intact animals. Canephron, Dorusim and diclofenac sodium have a distinct suppression of the degree of alteration, especially during the first two to three weeks. Along with this, the studied preparations suppress the process of exudation induced by carrageenan, and in this experiment as in the previous experiment, the effect of Dorusim was somewhat more expressed than canephron and it was practically not inferior to diclofenac sodium. It is noteworthy that Dorusim, as well as diclofenac sodium and canephron, clearly suppressed the proliferative phase of inflammation in the “cotton granuloma” model. It is believed that a new phytocomposition - Dorusim, like diclofenac sodium, suppresses all phases of multicomponent inflammation process occurring simultaneously in the inflammation focus. The revealed effect of the phytocomposition on various pathogenetic chains of inflammation, apparently, is due to the presence of biologically active substances in its composition: polyphenols, flavanoids, carotenoids, polysaccharides and others, which have anti-alterative and anti-exudative effects, and also help to accelerate the repair of damaged tissue. The obtained results justify the expediency of using the studied phytocomposition in the complex therapy of diseases accompanied by the development of inflammatory processes.


[1] Khakimov, Z.Z., Rakhmanov, A.Kh., Mavlanov, Sh.R. (2022). Anti-inflammatory activity of a mixture of medicinal plants. LLC "Tibbiyot nashrioti matbaa uyi", 228. 

[2] Chebotareva, N.V., Lysenko, L.V. (2022). Kidney damage associated with non-steroidal anti-inflammatory drugs. Nephrology and dialysis, 24:3:431-440. 

[3] Petureau, A., Raffray, M., Polard, E. and et al. (2021). Analysis of the association between emergency dialysis start in patients with end stage kidney disease and non-steroidal anti-inflammatory drugs, proton-pump inhibitors, and iodinated contrast agents. Journal of Nephrology, 34:5:1711-1723.

[4] Prozzi, R.G., Cañás, M., Urtasun, M.A. and et al. (2018). Riesgo cardiovascular de los anti-inflammatories no estereos. MEDICINA (Buenos Aires), 78: 349-355.

[5] Ying, X.H., Bao, D.N., Jiang, H.Y, Shi, Y.D. (2022). Maternal non-steroidal anti-inflammatory drug exposure during pregnancy and risk of miscarriage: a systematic review and meta-analysis. European Journal of Clinical Pharmacoly,78:2:171-180. 

[6] Gorovoy, P.G., Balyshev, M.E. (2017). Opportunities and prospects for the use of medicinal plants in the Russian Far East. Pacific Medical Journal, 3:5-14.

[7] Valieva, N.G. (2010). Medicinal plants are sources of biologically active substances. Scientific notes of the Kazan State Academy of Veterinary Medicine. N.E. Bauman, 203: 44-48.

[8] Kaysina, E.A., Marchenko, N.M., Smirnova, G.I. (2022). Phytotherapy in medical practice. Electronic collection of articles based on the material of the annual educational conference with international participation "Modern trends in the development of health saving technologies". 2022. 54-57. 

[9] Chekina, N.A., Razuvaeva, Ya.G., Chukaev, S.A. (2012). Evaluation of the spectrum of anti-inflammatory activity of a new complex agent of plant origin. Bulletin of the All-Russian Scientific Center of the Siberian Branch of the Russian Academy of Medical Sciences, 3:88:106-108.

[10] Mironov, A.N. (2012). Guidelines for conducting preclinical studies of drugs. Part one. Grif and K, Moscow, 944.

[11] Khakimov, Z.Z., Rakhmanov, A.Kh. Yuldashev, Zh.I. (2020). Influence of a cotton cellulose derivative on the course of aseptic arthritis. Pharmaceutical Bulletin of Uzbekistan, 2:3: 47-50.

[12] Khakimov, Z.Z., Rakhmanov, A.Kh., Yuldashev, J.I. (2021). Study of the Influence of Cotton Cellulose Derivatives on the Course of Carrageenan-Induced Arthritis in Rats. American Journal of Medicine and Medical Sciences, 11:12:926-929. 

doi: 10.5923/j.ajmms.20211112.17.

[13] Khakimov, Z.Z., Rakhmanov, A.Kh., Mavlanov, Sh.R. (2019). Study of the Influence of Dry Extract of Medicinal Plants on the Course of Carrageenan -Induced Inflammation. American Journal of Medicine and Medical Sciences, 9:8:307-310.

[14] Khakimov, Z. Z., Rakhmanov, A. H., Yuldashev, Zh.I. (2021). Study of the Anti-Inflammatory Activity of the Polymer Composition of Cotton Cellulose – Gossypol in Male Rats. American Journal of Medicine and Medical Sciences, 11:7:529-534 doi: 10.5923/j.ajmms. 0211107.06.

[15] Kong, Kh.Kh., Sibgatullina, R.R., Khabibrakhmanova, A.M. (2017). Possibility of using cellular test systems for screening for anti-inflammatory activity of new 5 (S) -mentyloxy derivatives of 2 (5H) -furanone. Kazan Medical Journal, 98:2:211-217.

[16] Necas, J., Bartosikova, L. (2013). Carrageenan: a review. Veterinary Medicine, 58:4:187-205.

[17] Koczka, N., Stefanovits-Bányai, E., Ombódi, A. (2018). Total Polyphenol Content and Antioxidant Capacity of Rosehips of Some Rosa Species. Medicines, 5:84. https://doi:10.3390/medicines5030084.

[18] Mihyaoui, A. EL., Castillo, M. E. C., Antonio Cano, A. (2021). Comparative study of wild chamomile plants from the north-west of Morocco: Bioactive components and total antioxidant activity. Journal of Medicinal Plants Research, 15:10:431-441. https://doi: 10.5897/JMPR2021.7159.

[19] Sugier, P., Seczyk, L., Sugier, D. and et al. (2021). Chemical Characteristics and Antioxidant Activity of Arctostaphylosuva-ursi L. Spreng. at the Southern Border of the Geographical Range of the Species in Europe. Molecules, 26:7692.

[20] Urabee, M. C., Abdulsattar, J.O., Nasif, Z. N., Al-Garawi Z.S. (2021). Extraction methods of Alhagi Maurorum (camel thorn) and its therapeutic applications. Journal of Physics: Conference Series. https://doi:10.1088/1742-6596/1853/1/012053.

[21] Wahab, S., Annadurai, S., Abullais, S.S. and et al. (2021). Glycyrrhiza glabra (Licorice): A Comprehensive. Review on Its Phytochemistry, Biological Activities, Clinical Evidence and Toxicology. Plants, 10: 2751. plants10122751.

[22] Anishchenko, L.V., Podolskaya, E.N. (2017). Encyclopedia of medicinal plants. Moscow. AST Publishing House.

[23] Khakimov, Z.Z., Babazhanov, A.U., Rakhmanov, A.Kh., Tursunova, L.I., Khadzhieva, and U.A. (2023). Multicomponent Photocomposition as A Source for Development New Anti-Inflammatory Medicines. Texas Journal of Medical Science, 20:29-32.

How to cite this paper

Study of the Influence of a New Phytocomposition on Various Phases of Aseptic Inflammation

How to cite this paper: Z. Z. Khakimov, A. U. Babazhanov, A. Kh Rakhmanov, L. I. Tursunova, U. A. Khadzhieva. (2023) Study of the Influence of a New Phytocomposition on Various Phases of Aseptic Inflammation. Advance in Biological Research4(1), 25-30.