Advance in Biological Research

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Article http://dx.doi.org/10.26855/abr.2023.06.005

Study of the Influence of a New Phytocomposition on Various Phases of Aseptic Inflammation

Z. Z. Khakimov1, A. U. Babazhanov2, A. Kh Rakhmanov1,*, L. I. Tursunova3, U. A. Khadzhieva3

1Tashkent Medical Academy, Tashkent, Uzbekistan. 

2Urgench Branch of the Tashkent Medical Academy, Urgench, Uzbekistan.

3Uzbek Research Chemical-Pharmaceutical Institute named after A. Sultanov, Uzbekistan.

*Corresponding author: A. Kh Rakhmanov

Published: August 1,2023

Abstract

It was found that the phytocomposition "Dorusim" helps to eliminate all phases of the multicomponent inflammation process in experimental studies conducted on mature white male rats. So, the development of a chemical burn - the process of alteration is not eliminated during the first month of observation in intact animals. Canephron, Dorusim and diclofenac sodium have a distinct suppression of the degree of alteration, especially during the first two to three weeks. Along with this, the studied preparations suppress the process of exudation induced by carrageenan, and in this experiment as in the previous experiment, the effect of Dorusim was somewhat more expressed than canephron and it was practically not inferior to diclofenac sodium. It is noteworthy that Dorusim, as well as diclofenac sodium and canephron, clearly suppressed the proliferative phase of inflammation in the “cotton granuloma” model. It is believed that a new phytocomposition - Dorusim, like diclofenac sodium, suppresses all phases of multicomponent inflammation process occurring simultaneously in the inflammation focus. The revealed effect of the phytocomposition on various pathogenetic chains of inflammation, apparently, is due to the presence of biologically active substances in its composition: polyphenols, flavanoids, carotenoids, polysaccharides and others, which have anti-alterative and anti-exudative effects, and also help to accelerate the repair of damaged tissue. The obtained results justify the expediency of using the studied phytocomposition in the complex therapy of diseases accompanied by the development of inflammatory processes.

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How to cite this paper

Study of the Influence of a New Phytocomposition on Various Phases of Aseptic Inflammation

How to cite this paper: Z. Z. Khakimov, A. U. Babazhanov, A. Kh Rakhmanov, L. I. Tursunova, U. A. Khadzhieva. (2023) Study of the Influence of a New Phytocomposition on Various Phases of Aseptic Inflammation. Advance in Biological Research4(1), 25-30.

DOI: http://dx.doi.org/10.26855/abr.2023.06.005