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International Journal of Clinical and Experimental Medicine Research

ISSN Online: 2575-7970 ISSN Print: 2575-7989 CODEN: IJCEMH
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ArticleOpen Access http://dx.doi.org/10.26855/ijcemr.2023.04.032

Neutrophil Extracellular Traps: A Potential New Target for the Treatment of Digestive Tract Tumors

Zaibo Zhang

Third Department of Surgery, The Fourth Hospital of Hebei Medical University, Shijiazhuang, Hebei, China.

*Corresponding author: Zaibo Zhang

Published: June 6,2023

Abstract

Neutrophil extracellular traps NETs (NETs) are extracellular fibrous reticular structures composed of DNA and multiple active proteins released by neutrophils. The development and metastasis of digestive tract tumors consists of multiple steps with complex mechanisms, which is one of the major causes of treatment failure and death of patients. Currently, there is increasing evidence that NETs are involved in the development of digestive tract tumors and are closely related to tumor proliferation and metastasis, and higher NETs are positively correlated with poor prognosis of tumors, which provides new ideas for the clinical management of digestive tract tumors. As an emerging research target, it is crucial for clinical discovery of relevant targets and subsequent research, but there are few clinical studies, which need to be further explored and the molecular mechanisms related to NETs need to be more clearly defined. This paper mainly reviews the research progress related to NETs and digestive tract tumors, in order to explore the clinical application prospects of NETs as potential therapeutic targets and related hotspots, so as to provide references for therapeutic drugs and methods for gastric cancer patients.

Keywords

Neutrophil extracellular traps, Gastrointestinal tumor, Summary of progress, Target

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How to cite this paper

Neutrophil Extracellular Traps: A Potential New Target for the Treatment of Digestive Tract Tumors

How to cite this paper:  Zaibo Zhang. (2023) Neutrophil Extracellular Traps: A Potential New Target for the Treatment of Digestive Tract Tumors. International Journal of Clinical and Experimental Medicine Research7(2), 269-272.

DOI: http://dx.doi.org/10.26855/ijcemr.2023.04.032