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International Journal of Clinical and Experimental Medicine Research

ISSN Online: 2575-7970 ISSN Print: 2575-7989 CODEN: IJCEMH
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ArticleOpen Access http://dx.doi.org/10.26855/ijcemr.2023.04.017

A Pan-cancer Study of the Expression Level of Selenoprotein SELENOO in Human Malignancies and Its Impact on Their Survival Prognosis

 Linglan Li*, Rongqiang Zhang

School of Public Health, Shaanxi University of Chinese Medicine, Xianyang, Shaanxi, China.

*Corresponding author:  Linglan Li

Published: June 2,2023

Abstract

The relationship between Selenium (Se) and selenium protein and cancer has become one of the hot issues in the field of cancer prevention and treatment. In this paper, SELENOO mRNA was firstly investigated in 27 human tumours by using GTEx database, CCLE database and TCGA database to explore its expression and further analyse its effect on the survival prognosis of 33 tumours. We also explored the correlation between SELENOO mRNA and tumour immune infiltration, tumour microenvironment (TME), immune neoantigens, immune checkpoint genes, tumour mutational load (TMB) and microsatellite instability (MSI), followed by GSEA analysis of high and low expression of SELENOO mRNA in pan-cancer. The results showed that aberrant expression of SELENOO mRNA correlated with the prognosis of a variety of tumours, particularly ACC, UVM, PAAD and UCEC. SELENOO mRNA expression was negatively correlated with TME, especially in LUSC and BLCA. It is suggested that SELENOO may be an important potential prognostic biomarker in pan-carcinoma and is associated with tumor immunity and metabolism.

Keywords

Pan-cancer, SELENOO, Tumour immunity, Prognosis, Biomarkers

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How to cite this paper

A Pan-cancer Study of the Expression Level of Selenoprotein SELENOO in Human Malignancies and Its Impact on Their Survival Prognosis

How to cite this paper:  Linglan Li, Rongqiang Zhang. (2023) A Pan-cancer Study of the Expression Level of Selenoprotein SELENOO in Human Malignancies and Its Impact on Their Survival Prognosis. International Journal of Clinical and Experimental Medicine Research7(2), 188-192.

DOI: http://dx.doi.org/10.26855/ijcemr.2023.04.017