Abstract
With the development of society and the deepening of the aging degree, the problems of neurodegenerative diseases are increasing, which has aroused widespread concern in society. Neurodegenerative diseases are seriously related to people's quality of life. Microglia are innate immune effector cells in the central nervous system and play an important role in the physiological processes of the central nervous system. The activation of microglia and inflammation-mediated neurotoxicity play an important role in some neurodegenerative diseases. The form of programmed cell death is apoptosis, caspase-8 is the apical component of the cell death pathways, and activated caspase-8 can drive classical caspase-dependent apoptosis. Recently, caspase-8 has also been implicated in intracellular inflammatory pathways. In particular, caspase-8 can participate in the synthesis and processing of IL-1β through canonical and non-canonical pathways. Therefore, in this review, we will discuss the related knowledge of caspase-8, which is initially associated with apoptosis, in mediating neuroinflammation in neurodegenerative diseases.
References
[1] Wang ZY, Liu J, Zhu Z, Su CF, Sreenivasmurthy SG, Iyaswamy A, et al. (2021). Traditional Chinese medicine compounds regulate autophagy for treating neurodegenerative disease: A mechanism review. Biomedicine & pharmacotherapy—Biomedecine & pharmacotherapy, 2021; 133:110968.
[2] Lee KH, Kang TB. (2019). The Molecular Links between Cell Death and Inflammasome. Cells, 2019; 8 (9).
[3] Yu Z, Jiang N, Su W, Zhuo Y. (2021). Necroptosis: A Novel Pathway in Neuroinflammation. Front Pharmacol, 2021; 12:701564.
[4] DeLaney AA, Berry CT, Christian DA, Hart A, Bjanes E, Wynosky-Dolfi MA, et al. (2019). Caspase-8 promotes c-Rel-dependent inflammatory cytokine expression and resistance against Toxoplasma gondii. Proceedings of the National Academy of Sciences of the United States of America, 2019; 116 (24):11926-11935.
[5] Gong, X., Xu, Z., & Xu, T. (2021). Caspase-8 signaling in neuropathic pain. Current Neuropharmacology, 19(7), 1018-1030.
[6] Zhang, Y., Guo, W., & Li, Z. (2020). The role of caspase-8 in Alzheimer's disease: Friend or foe? Frontiers in Aging Neuroscience, 12, 564641.
[7] Li, W., Wu, Z., & Yang, X. (2019). Caspase-8: A key player in the pathogenesis of multiple sclerosis. Clinical Immunology, 199, 1-6.
[8] Wang, T., Jia, Y., & Yang, Y. (2018). Caspase-8 and caspase-3 may be involved in mediating apoptosis in asphyxiated neonatal rats. Experimental and Therapeutic Medicine, 16(5), 3999-4003.
[9] Chen, X., Hu, L., & Liang, D. (2017). The differential expression of caspase-8 in motor neurons and astrocytes of mice with amyotrophic lateral sclerosis. Biochemistry and Cell Biology, 95(1), 1-6.